the association between fear of falling and quality of life for balance impairments based on hip and ankle strategies in the drug on- and off-phase of patients with idiopathic parkinson' disease

background: despite the negative effect of fear of falling during functioning and social participation of patients with parkinson&apos; disease, so far, only few studies have investigated its effect on the quality of life in these patients. we aimed to investigate the association between fear of falling and quality of life controlling for balance impairments based on hip and ankle strategy in drug on- and off-phase of patients with idiopathic parkinson&apos; disease.   methods: in this non-experimental cross-sectional study, 139 patients with idiopathic parkinson&apos; disease (100 male, 39 female) by mean± sd age of 60.2±12.27 years, mean±sd time since diagnosis of 6.7±5.53 years and mean±sd hoehn and yahr stage of 2.8±1.49 were selected by a simple non-probability method. balance function was measured by a functional reach test with hip and ankle strategy. the persian version of the self-completed fall efficacy scale-international and parkinson&apos;s disease quality of life questionnaire was used to evaluate fear of falling and quality of life, respectively.   results: the results showed that the score of all dimensions of quality of life (i.e., mobility, activities of daily living, emotional wellbeing, stigma, social support, cognition, communication and bodily discomfort) were significantly affected by the intensity of fear of falling. multiple regression analysis indicated a significant association between fear of falling and quality of life in a way that fear of falling explained 11% to 47% and 12% to 43% of variance in drug on-phase, as well as 8% to 45% and 9% to 48% of variance in the drug off-phase in dimensions of quality of life after controlling for balance function based on hip and ankle strategy, respectively. in the drug on-phase, the strongest association (r=0.85, p<0.001) was found between fear of falling and mobility dimension of quality of life. in the drug off-phase, the strongest relation was observed between fear of falling and mobility (r=0.82, p<0.001) as well as activities of daily living (r=0.78-0.79, p<0.001) dimensions.   conclusion: this study found that fear of falling affects the quality of life of patients with parkinson&apos; disease beyond its relationship with balance impairments based on the hip and ankle strategy in both drug on- and off-phase.